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Synlett
DOI: 10.1055/a-2726-4625
Synpacts

Preparation of chiral α-aryl ketones and aldehydes via Ni-catalyzed asymmetric cross-electrophile coupling

Authors

  • Canbin Qiu

    1   Center for Supramolecular and Catalytic Chemistry,Department of Chemistry, Shanghai University, Shanghai 200444, CN, Shanghai, China

  • Hegui Gong

    2   Institute of Nanoscience and Engineering, Henan University, Kaifeng, China (Ringgold ID: RIN12411)

Supported by: National Natural Science Foundation of China 22271182
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The preparation of tertiary α-aryl acetals and ketals has been achieved through a Ni-catalyzed reductive cross-coupling approach, utilizing a readily available Ni/Biox catalytic platform. This reaction demonstrates effective enantioselective control over unactivated alkyl radicals adjacent to sterically bulky acetal and ketal groups. The resulting protected tertiary α-aryl ketones and aldehydes are configurationally stable, offering opportunities for further chemical manipulations. In this short account, we summarize on our studies, organized into the following sections: 1. Introduction; 2. Arylation of α-iodoketals and -acetals. 3. Unsuccessful examples. 4. Conclusions.



Publication History

Received: 18 September 2025

Accepted: 17 October 2025

Accepted Manuscript online:
17 October 2025

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